Subject Line: Sustained Proliferative Signaling

Preview Text: Cancer Research: Explore these curated resources from CST experts to study sustained proliferative signaling in cancer.

 

The Importance of Growth Signals in Cancer Progression

Normal cells require ligand signals to trigger growth receptors on their cell surface to proliferate. But cancer cells can have mutations in these receptors, leading to uncontrolled replication. The resources below highlight some of the most important mechanisms and pathways contributing to this Hallmark of Cancer.
Text reads: Hallmarks of Cancer: Sustaining Proliferative Signaling

Targeting P13K/Akt Signaling


The PI3K/Akt pathway is critical for cell growth, proliferation, and survival, with many complex interactions linked to several diseases. Read about the pathways and diseases linked to PI3K/Akt signaling in this blog to see why it hits home for this CST scientist.
PI3K/Akt pathway diagram

 

P13K/Akt Signaling in Cellular Growth

 

The P13K/Akt signaling pathway is frequently dysregulated in tumors, making it an appealing therapeutic target for cancer and other diseases. Explore the players in this downloadable P13K/Akt signaling pathway diagram.
IF image of C2C12 cells

 

A powerful kinase predictor tool on PhosphoSitePlus

 

Wouldn't it be great if you could predict which protein kinase phosphorylates your site of interest? You can—with the CST® PhosphoSite Plus kinase predictor tool. Explore this powerful Kinase library 

developed in collaboration with MIT, Yale School of Medicine, and Weill Cornell Medical College.
Dendrogram of the human protein kinome

 

RELATED PRODUCTS
Confocal immunofluorescent analysis of Phospho-Akt expression in C2C12 cells.
Immunohistochemical analysis of EGF Receptor in paraffin-embedded human lung carcinoma.
Flow cytometric analysis of Phospho-PI3 Kinase p85 (Tyr458) and p55 (Tyr199) in NIH/3T3-Src cells.