Infographic depicting five phases of CAR cell characterization. Text reads: Detect: Quickly and easily evaluate CAR and target antigen expression, Analyze: Simplify immune cell activation, proliferation, viability, and signaling assays, Quantitate: Streamline measurement of CAR transduction efficiency and cell surface expression, Purify: Enrich CAR+ cells using either bead-based or FACS- based sorting with high specificity, and Translate: Directly interrogate the tumor microenvironment to detect infiltration of CAR-engineered cells.

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Tools for Fast and Flexible CAR Characterization

Flow cytometric analysis of live Jurkat cells (blue, negative) or Jurkat cells engineered to stably express an scFv-based Anti-CD20 CAR containing a G4S linker (green, positive) using G4S Linker (E7O2V) Rabbit mAb (PE Conjugate) or concentration-matched Rabbit (DA1E) mAb IgG XP® Isotype Control (PE Conjugate) #5742.

G4S Linker (E7O2V) Rabbit mAb conjugates

Flow cytometric analysis of live Jurkat cells and Jurkat cells engineered to stably express an scFv-based Anti-CD19 CAR containing a Whitlow/218 linker using Whitlow/218 Linker (E3U7Q) Rabbit mAb (Alexa Fluor® 647 Conjugate) and concentration-matched Rabbit (DA1E) mAb IgG XP® Isotype Control (Alexa Fluor® 647 Conjugate) #2985

Whitlow/218 Linker (E3U7Q) Rabbit mAb conjugates

Flow cytometric analysis of a mixed population containing live wild-type Jurkat cells and Jurkat cells engineered to express an scFv-based Anti-CD20 CAR containing a G4S linker, using G4S Linker (E7O2V) F(ab')2 Fragment (Alexa Fluor® 488 Conjugate)

G4S or Whitlow/218 Linker F(ab')2 Fragment conjugates