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Infographic illustrating five steps: Detect, Analyze, Quantitate, Purify, Translate (highlighted for emphasis).

Now Possible: Direct CAR Cell Assessment in Solid Tumors

 

When challenging solid tumors with CAR-engineered cells, a paramount

question is whether these cells are capable of entering the tumor microenvironment. But traditional methods have significant drawbacks. For the first time, you can confirm CAR protein expression in FFPE tissue specifically and directly, only from CST.

Assess CAR Expression in Tumors

CAR Expression in Tissue

 

Analyze the impact of CAR cell engineering on solid tumor penetration by examining IHC data of FFPE cancer tissue. See the CAR linker antibodies for IHC.

Immunohistochemical analysis of NSG mouse spleen transfused with primary human CAR-T cells targeting CD19 using Whitlow/218 Linker (F2G3S) Rabbit mAb.

Interrogate the Tumor Microenvironment

 

Investigate the tumor microenvironment with an IHC-validated portfolio of highly specific, unconjugated and conjugated antibodies. Innovative SignalStar® multiplex IHC is ideal for visualizing up to eight

biomarkers in the same panel. Explore IHC antibodies for TME investigation.

Immunohistochemical analysis of paraffin- embedded human papillary thyroid carcinoma using IL- 13RA2/CD213a2 (E7U7B) Rabbit mAb performed on the Leica BOND RX.

Simplify Translational CAR Research