Cellular senescence refers to a permanent cell cycle arrest. While it plays beneficial roles in tumor prevention, remodeling during development, and wound healing, accumulation of senescent cells over the course of a lifetime contributes to aging and age-related disease.
Since there is currently no universal marker of senescence, multiple markers in aggregate need to be assessed to evaluate the senescence status.
This Cellular Senescence eBook discusses how senescence is regulated in cells and how these characteristics of senescent cells can be detected using different methods:
- Cell cycle arrest
- Morphological and metabolic changes
- DNA damage and persistent DNA damage response
- Senescence-associated secretory phenotype
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