Despite progress in this field, there remains much unknown about the downstream targets and signaling cascades related to TREM2-dependent and TREM2-independent microglial activation. "Antibody tools capable of distinguishing microglial activation states and providing further clarity into the role particular proteins play in driving them are key to understanding the mechanisms related to neuroinflammation and neurodegeneration."
-Jordan Hirschfeld, Neuroscience Associate Development Scientist at CST
Characterize the Functional Role of TMEM119 in Microglia Activation
Visualize plaques and microglia, as seen in this amyloid mouse model of Alzheimer's disease. Fluorescent imaging with TMEM119 (E4B9S) Mouse mAb #98778 (red) reveals lower expression of TMEM119 in the amyloid plaque surrounding the microglia. GFAP (E4L7M) XP® Rabbit mAb #80788 (green) labels astrocytes.
β-Amyloid (D54D2) XP® Rabbit mAb (Alexa Fluor® 647 Conjugate #42284 completes the panel by staining plaques in this mouse brain sample.
Find the best TMEM119 antibody for your experiments here.
Visualize Disease-Associated Microglia with Iba1 Antibody Conjugates
Identify activated microglia in brain tissue like this amyloid mouse model of Alzheimer's disease, using:
Iba1/AIF-(E404W) XP® Rabbit mAb (Alexa Fluor® 555 Conjugate) #36618 (yellow) and plaque stains
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