Explore Immune Cell Signaling with These Pathway Diagrams
T Cell Receptor Signaling
Cell fate is determined through the regulation of cytokine production, cell survival, proliferation, and differentiation. Many of these signaling cascades are promoted throughT Cell Receptor (TCR) activation.
Conjugates for Flow Cytometric Analysis of T Cell Receptor Signaling
Flow cytometry is a strong technique for analyzing immune cells in a heterogenous population. Investigate T Cell Receptor Signaling with conjugates relevant to T Cell Signaling and validated for use by flow cytometry.
B Cell Receptor
The complexity of B cell antigen receptor (BCR) signaling permits many distinct outcomes, including survival, tolerance (anergy) or apoptosis, proliferation, and differentiation into antibody-producing cells or memory B cells.
The Jak/Stat pathway mediates the effects of cytokines, like erythropoietin, thrombopoietin, and G-CSF, which are protein drugs for the treatment of anemia, thrombocytopenia, and neutropenia. The pathway also mediates signaling by interferons, which are used as antiviral and antiproliferative agents. Researchers have found that dysregulated cytokine signaling contributes to cancer.
Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB, which regulate the expression of genes that influence a broad range of biological processes, including innate and adaptive immunity, inflammation, stress responses, B cell development, and lymphoid organogenesis.
Inflammasomes are multiprotein complexes that assemble in the cytosol after exposure to pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs) as part of immune response.
Immune signaling can be activated by cancer cells via adapter proteins like STING, which leads to dendritic cell maturation and the priming of CD8+ cells.
Immune Checkpoint Signaling
The inbuilt control mechanisms of the immune system that maintain self-tolerance and prevent collateral damage during a physiological immune response are referred to as immune checkpoints.
Conjugates for Flow Cytometric Analysis of Immune Cell Signaling
Examine critical immune checkpoints like TIM-3, Galectin-9, CD40L/CD40, PD-L1, and PD-1 with conjugates validated for flow cytometry.