Inflammasome Signaling
Inflammasomes are multiprotein complexes that assemble in the cytosol after exposure to pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs) as part of the innate immune system.
STING Signaling
Cancer cells can activate innate immune signaling through adapter proteins like STING, leading to dendritic cell maturation and priming of CD8+ cells.
NF-kB Signaling
These proteins function as dimeric transcription factors that regulate the expression of genes influencing a broad range of biological processes, including innate and adaptive immunity, inflammation, stress responses, B cell development, and lymphoid organogenesis.
Jak/Stat: IL-6
Jaks and Stats are critical components of many cytokine receptor systems; regulating growth, survival, differentiation, and pathogen resistance.