Many intricate pathways stand between uncontrolled cancerous cell division and stages of regulated cell cycle arrest or senescence. Studying the interactions between these proteins can reveal new ways to target cell cycle control mechanisms. Protein pathways that detect DNA damage, regulate cell cycle checkpoints, and determine whether a cell continues to divide provide attractive targets for the development of new therapeutics.
This eBook lays out the molecular pathways that control a cell’s commitment to divide, arrest the cell cycle, or enter into a senescent state. In it you will find key antibodies and assays to study various mechanisms of cell cycle control.