Mechanisms of Fibrosis Pathway

Fibrosis is the scarring and tissue hardening that is caused by the excess deposition of extracellular matrix (ECM) proteins by myofibroblasts in response to chronic inflammation. It contributes to the pathology of a number of fibrotic diseases of the liver, lung, and kidney and has been implicated in cancer progression. Understanding the cellular and molecular mechanisms underlying fibrosis is critical to enable therapeutic interventions that stem the progression of, or even reverse, fibrosis in multiple disease states.

Download our pathway to learn more about some of the key mechanisms and signaling pathways that contribute to fibrosis.